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Últimos itens adicionados do Acervo: Centro Hospitalar e Universitário de Coimbra

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Randomized phase III trial of bleomycin, vindesine, mitomycin-C, and cisplatin (BEMP) versus cisplatin (P) in disseminated squamous-cell carcinoma of the uterine cervix: an EORTC Gynecological Cancer Cooperative Group study

Vermorken, JB; Zanetta, G; Oliveira, CF; Van der Burg, ME; Lacave, AJ; Teodorovic, I
Fonte: Oxford Publicador: Oxford
Tipo: Artigo de Revista Científica
Publicado em //2001 Português
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PURPOSE: Three previous mitomycin-cisplatin-based chemotherapy trials conducted within the EORTC Gynecological Cancer Cooperative Group (GCCG) in patients with disseminated squamous-cell carcinoma of the uterine cervix (SCCUC) suggested that with such regimens a higher overall response rate and a higher complete response rate could be obtained compared to what might have been expected from cisplatin alone. In that respect the combination of bleomycin, vindesine (Eldesine), mitomycin C and cisplatin (BEMP) was the most promising. In the present study BEMP has been compared with the best single agent, cisplatin (P) in the expectation that improved response rates might translate into a better survival. PATIENTS AND METHODS: Eligible patients were those with SCCUC and disseminated measurable disease outside previously irradiated areas, aged < or = 75 years, with a WHO performance status < or = 2 and adequate bone marrow, renal, hepatic and pulmonary function, who gave consent according to regulations followed in individual institutions. Patients were randomized to BEMP: E 3 mg/m2 day 1, P 50 mg/m2 day 1, B 15 mg (24-hour infusion) day 2-4 and M 8 mg/m2 (at alternate cycles), or P 50 mg/m2. The first four cycles were given every 3 weeks (induction phase). Subsequent cycles were given every four weeks (maintenance phase)...

Pregnancy and its role in breast cancer

Martins, FC; Botelho, MF; Laranjo, M; Cabrita, AM; Torgal, MI; Oliveira, CF
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
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Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.

Avaliação da eficácia terapêutica do ceftriaxone versus piperacilina na profilaxia da infecção pós-histerectomia

Paulo, AS; Marta, J; Guerra, C; Tavares, M; Leitão, F; Riscado, I; Raimundo, D; Dias, MF; Ngan-Va, L; Oliveira, CF
Tipo: Artigo de Revista Científica
Publicado em //1995 Português
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Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias

Lemos, MC; Cabrita, FJ; Silva, HA; Vivan, M; Plácido, F; Regateiro, FJ
Fonte: Oxford Publicador: Oxford
Tipo: Artigo de Revista Científica
Publicado em //1999 Português
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Xenobiotic-metabolizing enzymes constitute an important line of defence against a variety of carcinogens. Many are polymorphic, constituting the basis for the wide inter-individual variation in metabolic capacity and possibly a source of variation in the susceptibility to chemical-induced carcinogenesis. The aim of this study was to determine the existence of any association between the main genetic polymorphisms of cytochrome P450 2D6 (CYP2D6), glutathione S-transferase M1 (GSTM1) and N-acetyltransferase 2 (NAT2) and an altered risk for haematological neoplasias. A total of 160 patients and 128 controls were genotyped by means of PCR-RFLP-based assays. Mutated alleles comprising CYP2D6*4, GSTM1*0, NAT2*5A, *5B, *5C, *6 and *7 were analysed along with the wild-type alleles. The results showed a higher frequency of CYP2D6 extensive metabolizers carrying two functional alleles in the leukaemia group, when compared with controls (76.6 versus 57.0%, P = 0.008). No differences were found in the case of Hodgkin and non-Hodgkin lymphomas. Analysis of the GSTM1 and NAT2 polymorphisms failed to show an association with any of the neoplasias, although a near significant increase in fast acetylators was also found in the leukaemia group (50.0 versus 35.9%...

Tumor desmoide simulando carcinoma da mama: um caso clínico

Cortesão, P; Andrade, MJ; Franco, S; Carvalho, G; Sousa, R; Silva, T; Torgal, I; Amaral, N; Oliveira, CF
Tipo: Artigo de Revista Científica
Publicado em //2000 Português
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Diagnóstico Densitométrico de Osteoporose: critérios de referência na população portuguesa

Pereira da Silva, JA; Carapito, H; Reis, P
Fonte: Sociedade Portuguesa de Reumatologia Publicador: Sociedade Portuguesa de Reumatologia
Tipo: Artigo de Revista Científica
Publicado em //1999 Português
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Rastreio aterosclerótico da Zona Centro

Serra e Silva, P; Meliço-Silvestre, A; Massano-Cardoso, S; Costa, A; Sampaio, L; Alexandrino, MB; Lourenço, A; Mota, O; Maia, C; Garret, V
Tipo: Artigo de Revista Científica
Publicado em //1983 Português
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Solitary frontal ulcer: A syphilitic gumma

Andrade, P; Mariano, A; Figueiredo, A
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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We report the case of a 30-year-old woman presenting with a single, deep, asymptomatic frontal ulcer that had developed in the previous two months without preceding trauma. Blood tests revealed reactive Rapid Plasma Reagin and Treponema pallidum hemagglutination assays. The diagnosis of syphilitic gumma was confirmed after histological analysis of the ulcer border. No other manifestations of late syphilis were detected. Ulcer healing was observed after treatment with benzathine penicillin and there was progressive reduction of follow-up serum RPR titers. The relevance of this case arises from its unusual presentation in a previously healthy immunocompetent individual.

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT)

Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, R
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em //2003 Português
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This study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measured and liver sections were analyzed in ANIT-treated rats (i.p. 80 mg/kg/week x 16 weeks). Mitochondrial parameters such as transmembrane potential, respiration, calcium capacity, alterations in permeability transition susceptibility and ATPase activity were monitored. Histologically, the most important features were the marked ductular proliferation, proliferation of mast cells and the presence of iron deposits in ANIT-treated liver. Mitochondria isolated from ANIT-treated rats showed no alterations in state 4 respiration, respiratory control ratio and ADP/O ratio, while state 3 respiration was significantly decreased. No changes were observed on transmembrane potential, but the repolarization rate was decreased in treated rats. Consistently with these data, there was a significant decrease in the ATPase activity of treated mitochondria. Associated with these parameters...

Cirurgia do AVC Isquémico

Barbosa, MD
Tipo: info:eu-repo/semantics/conferenceobject
Publicado em //2007 Português
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Termalismo nas Doenças Reumáticas: Panaceia ou Placebo?

Alexandre, M; Malcata, AB
Fonte: Sociedade Portuguesa de Reumatologia Publicador: Sociedade Portuguesa de Reumatologia
Tipo: Artigo de Revista Científica
Publicado em //2000 Português
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Aneurismas poplíteos: estudo retrospectivo

Baptista, A; Antunes, L; Moreira, J; Pereira, R; Gonçalves, A; Anacleto, G; Alegrio, J; Fonseca, M; Gonçalves, O; Matos, A
Fonte: Sociedade Portuguesa de Angiologia e Cirurgia Vascular Publicador: Sociedade Portuguesa de Angiologia e Cirurgia Vascular
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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Os autores elaboraram um estudo retrospectivo de todos os casos clínicos admitidos no seu Serviço com o diagnóstico de aneurisma poplíteo ao longo de 5 anos. Material e Métodos: Para atingir esse objectivo, procederam à consulta dos processos hospitalares de todos os doentes admitidos com o diagnóstico de aneurisma poplíteo entre 01 de Janeiro de 2004 e 31 de Dezembro de 2008. Resultados: De um total de 61 doentes, 37 (60,7%) apresentavam aneurismas bilaterais. Desses 61 doentes, 58 eram do sexo masculino e 3 do feminino, sendo a média de idades de 66,9 ± 11,6 anos. 36,1% dos doentes apresentavam também aneurismas noutras localizações. Os aneurismas eram, na sua maioria, assintomáticos. Quando sintomáticos, a forma de apresentação mais frequente foi a isquémia aguda por trombose do aneurisma. Dentro da totalidade dos aneurismas poplíteos (n=98), 37 foram operados electivamente, 29 de urgência e 32 não foram operados. As intervenções cirúrgicas de eleição foram a exclusão do aneurisma através de bypass femoro-poplíteo distal com veia safena interna (n=48) ou com prótese (n=16). As taxas de patência primária aos 30 dias foram de 98% com o uso de veia e de 68,8% com prótese, tendo motivado 3 amputações supracondilianas. Conclusões: Os aneurismas poplíteos são mais prevalentes no sexo masculino...

Physicochemical characterization of biomaterials commonly used in dentistry as bone substitutes--comparison with human bone

Figueiredo, M; Henriques, J; Martins, G; Guerra, F; Judas, F; Figueiredo, H
Fonte: Wiley Publicador: Wiley
Tipo: Artigo de Revista Científica
Publicado em //2010 Português
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The present work focuses on the physicochemical characterization of selected mineral-based biomaterials that are frequently used in dental applications. The selected materials are commercially available as granules from different biological origins: bovine, porcine, and coralline. Natural and calcined human bone were used for comparison purposes. Besides a classical rationalization of chemical composition and crystallinity, a major emphasis was placed on the measurement of various morphostructural properties such as particle size, porosity, density, and specific surface area. Such properties are crucial to acquiring a full interpretation of the in vivo performance. The studied samples exhibited distinct particle sizes (between 200 and 1000 microm) and shapes. Mercury intrusion revealed not only that the total sample porosity varied considerably (33% for OsteoBiol, 50% for PepGen P-15, and 60% for BioOss) but also that a significant percentage of that porosity corresponded to submicron pores. Biocoral was not analyzed by this technique as it possesses larger pores than those of the porosimeter upper limit. The density values determined for the calcined samples were close to the theoretical values of hydroxyapatite. However, the values for the collagenated samples were lower...

Artrite reumatóide: imagens de intervenções cirúrgicas

Judas, F; Costa, P
Fonte: Clínica Universitária de Ortopedia, HUC Publicador: Clínica Universitária de Ortopedia, HUC
Tipo: info:eu-repo/semantics/report
Publicado em //2010 Português
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O tratamento da artrite reumatóide assenta no trabalho de uma equipa multidisciplinar, sob a orientação de um reumatologista. A cirurgia representa, apenas, uma das etapas da planificação do tratamento global. A determinação das prioridades cirúrgicas é um problema específico da artrite reumatóide. A decisão de quando e que tipo de intervenção cirúrgica deve ser realizada em primeiro lugar, cabe a um grupo de trabalho, constituído pelo cirurgião, reumatologista e fisiatra. Cinco critérios podem influenciar essa decisão: a idade e motivação do paciente, o estádio da lesão articular, a natureza da articulação e a experiência do cirurgião. As intervenções cirúrgicas podem ser classificadas em três categorias (operações de primeira, segunda e terceira categoria), com base em cinco critérios: dor, função, estética, complicações e resultados tardios. O objectivo central deste trabalho tem a ver com a apresentação de imagens de intervenções cirúrgicas realizadas na Clínica Universitária de Ortopedia dos HUC no contexto do tratamento cirúrgico da artrite reumatóide, realçando o valor da planificação pré-operatória por forma a ser possível alcançar o melhor resultado. A cirurgia ocupa um lugar de primeiro plano no tratamento da artrite reumatóide. A motivação do doente...

Systemic granulomatosis disease in common variable immunodeficiency: case report

Sousa, N; Geraldes, I; Faria, E; Ferreira, I; Paiva, B; Chieira, C
Fonte: British Society for Immunology Publicador: British Society for Immunology
Tipo: Artigo de Revista Científica
Publicado em //2008 Português
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Testes epicutâneos a corticosteróides num período de dez anos

Santos, A; Andrade, P; Loureiro, C; Gonçalo, Margarida
Fonte: Sociedade Portuguesa de Imunoalergologia Publicador: Sociedade Portuguesa de Imunoalergologia
Tipo: Artigo de Revista Científica
Publicado em //2011 Português
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Wrist Arthrodesis: Clinical and Ultrasonographic Trial

Oliveira, JP; Serra, S; Néri, A
Fonte: Serviço de Ortopedia Publicador: Serviço de Ortopedia
Tipo: info:eu-repo/semantics/conferenceobject
Publicado em //2012 Português
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INTRODUCTION: The wrist arthrodesis has become a well-established procedure on the treatment of various diseases that affect the radiocarpal joint with the objective of pain relief and restoration of joint stability, allowing a recovery of gripping function and lifestyle. OBJECTIVES: Evaluate the functional outcomes of wrist arthrodesis in patients with advanced symptomatic inflammatory or degenerative arthritis and evaluate the residual synovitis by ultrasonography. METHODS: Review the patients who underwent a total wrist arthrodesis in our Hospital between 1999 and 2009, by a comparative and functional study. The study population was divided into two groups: Inflammatory Rheumatic Disease (IRD group) and another that included the remaining cases (RC group). For functional evaluation we used the Buck-Gramcko&Lohman (BGL) Evaluation for Total Wrist Function and the Disabilities of the Arm, Shoulder and Hand (DASH) Score. Pain levels were measured pre- and postoperatively according to the Visual Analogue Scale (VAS). A General Electric P5 Power Doppler Ultrasound with a high-resolution linear 7-12 MHz array was used to identify local synovitis. Mann-Whitney, Wilcoxon and Chi-Square tests were applied for statistical evaluation. p

Antiagregantes:quem e quando parar?

Matias, F
Fonte: Serviço de Anestesiologia, Centro Hospitalar e Universitário de Coimbra Publicador: Serviço de Anestesiologia, Centro Hospitalar e Universitário de Coimbra
Tipo: info:eu-repo/semantics/conferenceobject
Publicado em //2012 Português
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Renal allograft complicated with renal artery stenosis: Case 8038

Santiago, I; Canelas, A; Pinto, AP
Fonte: European Society of Radiology Publicador: European Society of Radiology
Tipo: Artigo de Revista Científica
Publicado em 01/12/2009 Português
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Cardiac tumors

Santiago, I; Portilha, MA; Gonçalves, B; Rodrigues, H; Donato, P; Caseiro-Alves, F
Tipo: info:eu-repo/semantics/conferenceobject
Publicado em //2009 Português
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